PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling
نویسندگان
چکیده
منابع مشابه
PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα activity is not understood. Here, we show that PIASy-mediated small ubiquitin-like modifier 2/3 (SUMO2/3) modification of TopoIIα strongly inhibits TopoIIα decatenation activity. ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2014
ISSN: 0270-7306
DOI: 10.1128/mcb.00312-14